What is telomerase and its function?
Telomerase is the enzyme responsible for maintenance of the length of telomeres by addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes and stem and tumor cells. Besides catalytic telomere elongation, independent telomerase functions can be also involved in cell cycle regulation.
What is the function of telomere?
Their job is to stop the ends of chromosomes from fraying or sticking to each other, much like the plastic tips on the ends of shoelaces. Telomeres also play an important role in making sure our DNA gets copied properly when cells divide.
What is the main ingredient in TA-65?
herb Astragalus membranaceus
What is TA-65 made from?
TA-65 is a plant-based compound made from isolated extracts of Astragalus membranaceus, and is a patented product of T.A. Sciences®.
How do telomeres affect aging?
Telomere length shortens with age. Progressive shortening of telomeres leads to senescence, apoptosis, or oncogenic transformation of somatic cells, affecting the health and lifespan of an individual. Shorter telomeres have been associated with increased incidence of diseases and poor survival.
What is the meaning of telomeres?
Telomeres are distinctive structures found at the ends of our chromosomes. They consist of the same short DNA sequence repeated over and over again. They consist of the same sequence of bases ?repeated over and over. In humans the telomere sequence is TTAGGG.
How many Telomeres are in a chromosome?
What is the sequence composition of telomeres?
Telomere, segment of DNA occurring at the ends of chromosomes in eukaryotic cells (cells containing a clearly defined nucleus). Telomeres are made up of repeated segments of DNA that consist of the sequence 5′-TTAGGG-3′ (in which T, A, and G are the bases thymine, adenine, and guanine, respectively).
What is the difference between telomerase and telomeres?
Telomeres function by preventing chromosomes from losing base pair sequences at their ends. Telomerase, also called telomere terminal transferase, is an enzyme made of protein and RNA subunits that elongates chromosomes by adding TTAGGG sequences to the end of existing chromosomes.
Which cell has the highest telomerase activity?
For example, gut stem cells or haematopoietic stem cells show highly active telomerase, while telomerase in heart and brain stem cells is far less active, since these organs have a slower turnover rate. The genes for the telomerase subunits in humans are localized at chromosome 5p15 (for TERT) and 3q26 (for TR).
How is telomerase activity measured?
Telomerase activity is measured by evaluating the amount of inorganic pyrophosphate generated in PCR amplification of telomerase elongation product, with use of the sensitive enzymatic luminometric inorganic pyrophosphate detection assay (ELIDA).
How do cancer cells use the enzyme telomerase?
Cancer cells achieve proliferative immortality by activating or upregulating the normally silent human TERT gene (hTERT) that encodes telomerase, a protein with reverse transcriptase activity that complexes with other proteins and a functional RNA (encoded by hTR, also called hTERC) to make a ribonucleoprotein enzyme …
Which enzyme is used first in DNA replication?